Dr.ANKIT SINGH TOMAR, T18506
PURPOSE: Efficacy and safety of NAC with intent to enucleate in advanced Rb
METHODS: Retrospective interventional case series of 125 eyes of 125 patients, 30 group E, 79 group E with clinical risk factors and 16 orbital Rb, unsafe or unwilling for primary enucleation, who underwent 6 cycles of NAC. Eye salvage and systemic metastasis were the outcome measures.
RESULTS: Mean age was 23.6±18.3m. Eye salvage was possible in 28(22%) with focal therapy along with NAC. Of 97(78%) eyes enucleated following NAC, 10(10.3%) showed histopathological risk factors and received further adjuvant chemotherapy. At 23.46±13.41m follow-up, 2(3%) patients with enucleated eyes and none with salvaged eyes developed systemic metastasis.
CONCLUSION: NAC with intended deferred enucleation appears safe, and may be offered to patients with advanced retinoblastoma, unsafe or unwilling (with risk of treatment abandonment) for immediate primary enucleation. About a fifth of such eyes may be salvaged.
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