Dr.sarvesswaran prakash, P21493
BACKGROUND: Vogt-Koyanagi-Harada(VKH) disease is a bilateral, granulomatous panuveitis with Neurologic and Cutaneous manifestations. Late complications includes cataract, glaucoma, choroidal neovascularization(CNVM), sub retinal fibroses(SRF) among them CNVM and SRF carries very poor visual prognosis.
CASE REPORT: We report a case of 25 years old female who presented with bilateral granulomatous panuveitis and multiple serous RD. She was diagnosed as a case of VKH was started on oral and periocular steroids for which she responded well but she had recurrent episodes of anterior uveitis with Methotrexate and MMF and later cyclophosphamide was started. Following uncontrolled inflammation she developed peri-papillary CNVM in RE for which intra-vitreal Avastin was given. Recent OCT showed regression of CNVM.
CONCLUSION: Main therapeutic goal for CNVM is to control underlying recurrent inflammation and VEGF down regulation with immunosupression and anti-VEGF therapy.
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