Dr.Mangesh Shelke, S20966
Abstract: A 7-year-old girl presented with LE superior orbital apex syndrome VA LE 4/60, upper lid ptosis, fundus- show papilledema. MRI brain/orbit evidence of enhancing soft tissue lesion with T1W low signal, T2W flair mixed signal measuring 4.8×3.1 cm noticed in left cavernous sinus region extending in to medial quadrant and cavernous sinus 2,3,4,5 & 6 cranial nerve, suggestive of small round cell neoplasm. After incision biopsy of left orbital mass. H & E show structure of tumour tissue by proliferation of mixed glial cell in fibrillary matrix with area of pleomorphism, mitosis and individual cell necrosis. Area of clear cell, cellular and nuclear pleomorphism, cellular crowding & glioneuronal cell seen. IHC and GFAP weak positivity, vimentin diffuse positivity. Over all feature were diagnostic WHO grade 3 high infiltrative glioma suggestive of mixed glioma, more commonly seen in adults. This case is rare because of high grade malignant glioma seen in childhood.
Leave a Comment