FP328 : MILLER FISHER SYNDROME PRESENTING WITH IDIOPATHIC CENTRAL SEROUS RETINOPATHY[ICSC]:RARE ASSOCIATION

Dr.HARSH VARDHAN SINGH, S20121

Miller Fisher syndrome (MFS) is a rare autoimmune disorder characterised with acute onset of diplopia, b/l complete ophthalmoplegia & other neurological signs like ataxia & areflexia. It is known to be a variant of Guillain Barre syndrome (GBS) with risk of progression to GBS in rare instances. Unlike GBS, Typical MFS is not life threatening. It’s annual incidence is 0.09cases/100,000 population . As it is similar with GBS in early stage, prompt clinical diagnosis & follow-up is needed. MFS has never been reported with ICSC in past. A 40 yr male presented with acute onset DOV R/E (Vd: FC1m OD,6/9 OS), diplopia & other neurological features suggestive of typical MFS with B.P. 150/100mm at the time of presentation with no prior history of hypertension. On OCT & FFA evaluation he was diagnosed with ICSC right eye along with typical MFS. Patient was managed conservatively without steroid Tx & his vision improved to 6/6 OU along with resolution of ICSC by 3rd week of presentation.