Dr.Sameera.V.V, S19235
Purpose: To investigate the optical coherence tomography (OCT) biomarkers in refractory DME (Diabetic Macular oedema ) pre and post treatment by intravitreal dexamethasone (DEX) implant and predict the treatment outcome post injection. Methods: A retrospective, observational cohort study in a single centre with 68 eyes of 49 patients treated with DEX implant for refractory DME were included.The morphological features in the SD- OCT pre and post to DEX implants such as subretinal fluid (SRF),cystoid changes, IS-OS continuity, and location/ number of hyperreflective foci (HRF), Disorganisation of inner retinal layers (DRIL), vitreomacular interface abnormalities, presence of ERM were compared and evaluated .The BCVA and CMT were recorded at baseline and at 1, 2 and 3 months.The presence of SRF, lesser number of HRF, maintained integrity of the IS-OS layer and absent DRIL were predictive of better visual outcome .The mean CMT improved from 373.65µ to 202.34 µ at 3 months (p <0.001).
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