Dr.Shyam Sundar Das Mohapatra, M21525
A 4 years old boy presented with redness of right eye, discharge and itching of both eyes. Blistering skin lesions were present over elbows, fingers, knees, legs, toes, back of pinna and dystrophic nail change. Lesions started since three months of age. Diagnosed as Autosomal Dominanat Dystrophic Epidermolysis Bullosa (DDEB), by biopsy and genetic analysis. On anterior segment examination, episcleral congestion with a small blister formation in superior temporal quadrant of conjunctiva in right eye. On investigation, irregular astigmatism was found in both eyes by corneal topography.
Ophthalmic complications are common in DDEB, but incidence of ocular structure involvement varies widely among different patients and different subtypes. Conjunctival blistering without eyelid or corneal disease is one of most common ophthalmic complication. Protection of eyes from minor trauma such as rubbing may help to prevent ocular complications. Major treatment modality is use of ocular lubricants.
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