Dr.Charuta Puranik, P13233
Perhaps the best measurement of impact of research is increased knowledge leading to scientific advancement. Genetics:
Vision research community has vigorously worked leading to great successes in identifying disease-causing genetic variants across the entire spectrum of ocular diseases. Identifying risk factors in age-related macular degeneration, diabetic retinopathy, myopia, glaucoma, Fuchs’ dystrophy cataract, keratoconus, & dry eyes has had some success.
Gene Therapy
The successful elucidation of the genetic etiology of ocular diseases has paved the way for the development of gene-based therapies. The eye represents an ideal target for gene and cell therapies due to its small size, accessibility the blood retinal barrier and a stable retinal cell population.
Optogenetics
In advanced photoreceptor degeneration, new strategies allow control of neural activity via genetic introduction of light-sensitive proteins such as channelrhodopsin and halorhodopsin.
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